NURAWISE
Evidence Methodology
EVIDENCE METHODOLOGY
How NuraWise judges the strength of supplement evidence.
NuraWise separates established nutritional roles from supplement claims. We evaluate the quality, consistency, directness, and practical relevance of the available evidence before assigning an evidence grade.
Evidence Grades
A — Strong
Supported by consistent findings from high-quality human evidence and authoritative guidance, with limited meaningful uncertainty.
B — Moderate
Supported by useful human evidence, but with limitations such as smaller studies, mixed results, or less certainty about practical effect size.
C — Limited
Early or inconsistent evidence suggests a possible effect, but the claim is not established well enough for a confident conclusion.
D — Insufficient
Evidence is too weak, indirect, conflicting, or absent to support a meaningful conclusion.
Source Hierarchy
Tier 1 — Public & Regulatory Sources
Government and public-health sources such as NIH, FDA, CDC, NHS, and EFSA are prioritized for intake recommendations, safety limits, and regulatory context.
Tier 2 — Scientific Literature
Systematic reviews, meta-analyses, randomized controlled trials, and peer-reviewed studies are used to evaluate efficacy and uncertainty.
Tier 3 — Product & Certification Sources
Official labels, manufacturer documentation, and certification information are used to verify formulation, dose, testing claims, and product details.
Tier 4 — Commercial & General Sources
Retailer pages, general websites, and user reports may provide context, but they are not treated as primary scientific evidence for efficacy.
How We Interpret Claims
We distinguish between a nutrient’s established biological role and a claim that taking more of that nutrient as a supplement will improve a specific outcome. A plausible mechanism does not automatically equal a proven benefit, and a statistically significant result does not always mean a meaningful real-world effect.
When evidence is mixed or uncertain, NuraWise states that uncertainty directly rather than forcing a simple yes-or-no conclusion.
How Evidence Connects to Reviews
Evidence grades inform the NuraWise review process, but they are only one part of a product evaluation. Product form, dose, label transparency, testing information, additives, value, and convenience are assessed separately.
Ongoing Review
Evidence can change. NuraWise revisits safety limits, dosage guidance, product labels, and major new research when material updates occur, and distinguishes current evidence from older or preliminary findings.